TTC5

Across TCGA pan-cancer cohorts, TTC5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TTC5 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TTC5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TTC5 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where TTC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.226	1.000	.013	42	view →
LSCC	OS	Median	II,III,IV	0.906	0.647	.003	19	view →
PDAC	DFS	Median	All	0.843	0.693	.030	9	view →
CCRCC	OS	Median	All	0.920	0.767	.007	5	view →
OV	DFS	Median	All	0.867	1.000	.049	4	view →
GBM	OS	Median	All	0.639	0.440	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TTC5–HNSC (OS)

Open the HNSC breakdown →