TTC4

Across TCGA patient cohorts, TTC4 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,601 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TTC4-associated proteins across cancer lineages are POLR2B, AQR, and NONO. Each is linked with TTC4 in more than 4 cancer types. Because this analysis shows association rather than direction, both TTC4-to-partner and partner-to-TTC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TTC4 versus POLR2B in LSCC, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC4→partner) and Y-score (partner→TTC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POLR2B →	+0.201	+0.273	<.001	<.001	3	5
LSCC	AQR →	+0.328	+0.297	<.001	<.001	3	4
LSCC	NONO →	+0.184	+0.264	<.001	<.001	3	4
COAD	RSBN1 →	+0.281	+0.177	.001	.002	3	4
LSCC	SMARCB1 →	+0.222	+0.237	<.001	<.001	3	4
LSCC	SPIN1 →	+0.271	+0.159	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,601 associations by consensus.

TTC4 vs POLR2B — LSCC

Explore this scatter interactively →