TTC39B

Across TCGA pan-cancer cohorts, TTC39B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TTC39B data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TTC39B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TTC39B expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where TTC39B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.892	0.680	.004	30	view →
LUAD	DFS	Median	II,III,IV	0.883	0.241	.004	15	view →
PDAC	OS	Quartile	II,III,IV	0.776	0.379	.001	13	view →
LSCC	OS	Quartile	All	1.000	0.892	.015	5	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.542	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TTC39B–HNSC (DFS)

Open the HNSC breakdown →