TTC39B

Across TCGA patient cohorts, TTC39B mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC39B-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and A-Raf_pS299. Each is linked with TTC39B in more than 2 cancer types. Because this analysis shows association rather than direction, both TTC39B-to-partner and partner-to-TTC39B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TTC39B-low versus TTC39B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC39B→partner) and Y-score (partner→TTC39B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.558	+1.604	.022	.041	3	3
UCEC	14-3-3_beta →	-0.104	-2.432	.012	.018	3	2
UCEC	A-Raf_pS299 →	-0.109	-2.584	.027	.010	3	2
UCEC	PR →	-0.228	-2.999	.027	.035	3	2
UCEC	Di-Ras3 →	-0.152	-1.807	.013	.027	3	2
UCEC	EGFR_pY1068 →	-0.267	-2.584	.010	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Caspase-7-cleavedD198 by TTC39B expression — UCEC

Explore this box plot interactively →