TTC39A

Across TCGA pan-cancer cohorts, TTC39A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TTC39A data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TTC39A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TTC39A expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where TTC39A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.882	.022	78	view →
PDAC	DFS	Tertile	All	0.532	0.286	<.001	67	view →
HNSC	DFS	Quartile	II,III,IV	0.762	0.452	.005	32	view →
GBM	OS	Tertile	All	0.271	0.532	.003	25	view →
UCEC	DFS	Median	II,III,IV	0.866	0.531	.026	12	view →
CCRCC	OS	Tertile	All	0.739	0.960	.007	7	view →
LSCC	OS	Tertile	All	0.657	0.851	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TTC39A–COAD (DFS)

Open the COAD breakdown →