TTC39A

Across TCGA patient cohorts, TTC39A mutation is significantly associated with the RNA expression of many other genes, with 3,536 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC39A-associated genes across cancer lineages are KRTAP10-12, CENPM, and ADNP2. Each is linked with TTC39A in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC39A-to-partner and partner-to-TTC39A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-12 grouped by TTC39A-low versus TTC39A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC39A→partner) and Y-score (partner→TTC39A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KRTAP10-12 →	+0.040	+5.444	<.001	.002	3	2
COAD	CENPM →	+0.879	+3.332	<.001	.005	3	2
UCEC	ADNP2 →	+0.631	+3.939	<.001	<.001	3	2
COAD	VAPA →	+0.538	+3.196	<.001	.009	3	2
UCEC	GPI →	+0.384	+1.470	.005	.008	3	2
COAD	PFN1 →	+0.583	+3.625	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,536 associations by consensus.

KRTAP10-12 by TTC39A expression — LUAD

Explore this box plot interactively →