TTC39A

Across TCGA cell cohorts, TTC39A mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TTC39A-associated genes across cancer lineages are AVP, DPRX, and PRAMEF6. Each is linked with TTC39A in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC39A-to-partner and partner-to-TTC39A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by TTC39A-low versus TTC39A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC39A→partner) and Y-score (partner→TTC39A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
CNS	DPRX →	+0.048	+4.321	<.001	.009	3	1
CNS	PRAMEF6 →	+0.098	+4.754	<.001	.005	3	1
LARGE_INTESTINE	SIGLEC11 →	+0.022	+3.584	.002	.007	3	1
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	1
SKIN	NPAP1 →	+0.004	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

AVP by TTC39A expression — BLOOD_Lymphoma

Explore this box plot interactively →