TTC38

Across TCGA patient cohorts, TTC38 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC38-associated genes across cancer lineages are eIF4E, mTOR_pS2448, and cIAP. Each is linked with TTC38 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC38-to-partner and partner-to-TTC38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TTC38-low versus TTC38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC38→partner) and Y-score (partner→TTC38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.171	+2.222	.024	.010	3	2
UCEC	mTOR_pS2448 →	-0.149	-3.571	.005	.002	3	2
UCEC	cIAP →	+0.102	+2.125	.039	.010	3	2
UCEC	4E-BP1 →	+0.289	+1.904	.003	.029	3	2
UCEC	A-Raf_pS299 →	-0.098	-3.584	.022	.002	3	1
UCEC	ERK2 →	+0.189	+2.222	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eIF4E by TTC38 expression — UCEC

Explore this box plot interactively →