TTC38

Across TCGA cell cohorts, TTC38 mutation is significantly associated with the RNA expression of many other genes, with 228 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC38-associated genes across cancer lineages are L3MBTL2, POLR3H, and TRMU. Each is linked with TTC38 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC38-to-partner and partner-to-TTC38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L3MBTL2 grouped by TTC38-low versus TTC38-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC38→partner) and Y-score (partner→TTC38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	L3MBTL2 →	+0.602	+3.364	.002	.002	3	1
LARGE_INTESTINE	POLR3H →	+0.780	+3.364	.001	.002	3	1
LARGE_INTESTINE	TRMU →	+0.647	+3.169	.001	.006	3	1
LARGE_INTESTINE	PITX3 →	+0.122	+2.736	<.001	.004	3	1
LARGE_INTESTINE	TRIM37 →	+0.611	+3.364	.004	.002	3	1
LARGE_INTESTINE	C1QBP →	+0.723	+3.451	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 228 associations by consensus.

L3MBTL2 by TTC38 expression — LARGE_INTESTINE

Explore this box plot interactively →