Across TCGA pan-cancer cohorts, TTC37 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TTC37’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where TTC37 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TTC37 is over-expressed in tumor, although a few such as PDAC and LSCC show the opposite, repressed pattern.

PDAC, LSCC, and COAD are the cancer types where TTC37 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTC37 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−0.412	<.001	7	view →
LSCC	All	II,III,IV	−0.162	<.001	6	view →
COAD	All	II,III,IV	−0.065	.017	3	view →
LUAD	All	All	+0.067	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TTC37 RNA expression & survival · all TTC37 data types