Across TCGA cell cohorts, TTC37 mutation is significantly associated with the RNA expression of many other genes, with 412 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC37-associated genes across cancer lineages are TNRC6B, OR2L5, and GYS2. Each is linked with TTC37 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC37-to-partner and partner-to-TTC37 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC37→partner) and Y-score (partner→TTC37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNRC6B →	+0.815	+3.212	<.001	.006	3	2
LUNG_NSCLC_LUAD	OR2L5 →	+0.015	+4.472	<.001	.001	3	2
OESOPHAGUS	GYS2 →	+0.066	+4.017	.003	.007	3	1
OESOPHAGUS	RTP5 →	+0.047	+4.392	<.001	.003	3	1
OESOPHAGUS	DEFA1 →	+0.089	+4.392	<.001	.003	3	1
LUNG_SCLC	LUZP4 →	+1.000	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 412 associations by consensus.

Exploration

TTC37 survival (RNA) · tumor vs normal (RNA) · all TTC37 data types