Across TCGA cell cohorts, TTC34 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC34-associated genes across cancer lineages are CEACAM4, DEFB133, and PPIAL4F. Each is linked with TTC34 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC34-to-partner and partner-to-TTC34 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC34→partner) and Y-score (partner→TTC34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CEACAM4 →	+0.092	+4.887	<.001	.009	3	1
CNS	DEFB133 →	+0.035	+5.357	<.001	.001	3	1
CNS	PPIAL4F →	+0.135	+4.832	<.001	.002	3	1
LARGE_INTESTINE	RBMY1B →	+0.006	+5.415	<.001	.004	3	1
LARGE_INTESTINE	RBMY1D →	+0.006	+5.415	<.001	.004	3	1
LARGE_INTESTINE	ETDC →	+0.800	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

TTC34 survival (RNA) · tumor vs normal (RNA) · all TTC34 data types