TTC3

Across TCGA pan-cancer cohorts, TTC3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TTC3 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TTC3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TTC3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where TTC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	III,IV	0.318	1.000	.013	32	view →
HNSC	DFS	Tertile	III,IV	0.909	0.626	.015	8	view →
LUAD	OS	Tertile	III,IV	0.647	0.267	.047	2	view →
CCRCC	OS	Median	All	1.000	0.898	.038	2	view →
PDAC	DFS	Median	II,III,IV	0.756	0.855	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TTC3–UCEC (OS)

Open the UCEC breakdown →