TTC3

Across TCGA patient cohorts, TTC3 mutation is significantly associated with the RNA expression of many other genes, with 6,398 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC3-associated genes across cancer lineages are SPAG5, CORT, and PGD. Each is linked with TTC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TTC3-to-partner and partner-to-TTC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPAG5 grouped by TTC3-low versus TTC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC3→partner) and Y-score (partner→TTC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPAG5 →	+0.682	+2.353	<.001	<.001	3	4
UCEC	CORT →	+0.334	+1.317	<.001	<.001	3	4
UCEC	PGD →	+0.366	+1.600	.001	.001	3	4
UCEC	UHRF1 →	+0.956	+2.180	<.001	<.001	3	3
UCEC	OIP5 →	+0.848	+2.021	<.001	<.001	3	3
COAD	GOT1 →	+0.575	+3.469	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,398 associations by consensus.

SPAG5 by TTC3 expression — UCEC

Explore this box plot interactively →