TTC3

Across TCGA patient cohorts, TTC3 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC3-associated genes across cancer lineages are GAPDH, PCNA, and ASNS. Each is linked with TTC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TTC3-to-partner and partner-to-TTC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by TTC3-low versus TTC3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC3→partner) and Y-score (partner→TTC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.527	+3.593	.016	.001	2	4
COAD	PCNA →	+0.219	+2.820	.042	.035	3	3
COAD	ASNS →	+0.684	+3.321	<.001	.009	3	3
BLCA	EGFR →	-0.268	-1.700	.034	.043	3	2
SKCM	PRDX1 →	+0.353	+1.700	.002	.040	3	2
BLCA	DJ-1 →	+0.120	+2.182	.049	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

GAPDH by TTC3 expression — COAD

Explore this box plot interactively →