TTC3

Across TCGA cell cohorts, TTC3 mutation is significantly associated with the RNA expression of many other genes, with 1,660 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC3-associated genes across cancer lineages are E2F2, IQCC, and SNRNP40. Each is linked with TTC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TTC3-to-partner and partner-to-TTC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, E2F2 grouped by TTC3-low versus TTC3-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC3→partner) and Y-score (partner→TTC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	E2F2 →	+0.990	+2.944	.003	.007	3	4
LARGE_INTESTINE	IQCC →	+0.438	+3.584	.002	<.001	3	4
LARGE_INTESTINE	SNRNP40 →	+0.559	+2.265	.001	.001	3	3
LARGE_INTESTINE	SETD6 →	+0.549	+2.949	.006	<.001	2	4
LARGE_INTESTINE	ELP6 →	+0.470	+4.043	<.001	<.001	3	3
LARGE_INTESTINE	ZNF232 →	+0.917	+3.672	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,660 associations by consensus.

E2F2 by TTC3 expression — STOMACH

Explore this box plot interactively →