TTC28

Across TCGA patient cohorts, TTC28 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC28-associated genes across cancer lineages are EGFR_pY1068, GAPDH, and MSH6. Each is linked with TTC28 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC28-to-partner and partner-to-TTC28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TTC28-low versus TTC28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC28→partner) and Y-score (partner→TTC28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.174	-1.000	.010	.026	3	2
COAD	GAPDH →	+0.512	+3.459	.004	.004	3	2
UCEC	MSH6 →	-0.370	-1.826	<.001	.001	3	2
COAD	TFRC →	+0.500	+3.033	.007	.017	3	2
COAD	ATM →	-0.690	-3.700	<.001	.001	3	2
COAD	Caspase-7-cleavedD198 →	+1.519	+3.923	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

EGFR_pY1068 by TTC28 expression — UCEC

Explore this box plot interactively →