TTC27

Across TCGA pan-cancer cohorts, TTC27 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TTC27 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher TTC27 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TTC27 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

SCLC, UCEC, and KIRP are the cancer types where TTC27 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.137	0.700	<.001	48	view →
UCEC	OS	Median	II,III,IV	1.000	0.315	.002	36	view →
KIRP	OS	Median	All	0.148	0.904	<.001	25	view →
LUSC	DFS	Median	III,IV	0.079	0.658	<.001	12	view →
LIHC	DFS	Median	All	0.110	0.559	<.001	12	view →
HNSC	DFS	Median	All	1.000	0.319	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TTC27–SCLC (OS)

Open the SCLC breakdown →