TTC27

Across TCGA pan-cancer cohorts, TTC27 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TTC27 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TTC27 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TTC27 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

PDAC, LUAD, and UCEC are the cancer types where TTC27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.308	0.667	.002	60	view →
LUAD	DFS	Tertile	III,IV	0.662	0.210	.012	16	view →
UCEC	DFS	Quartile	III,IV	1.000	0.383	.040	8	view →
GBM	DFS	Tertile	All	0.244	0.438	.015	7	view →
CCRCC	OS	Quartile	III,IV	0.474	0.768	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TTC27–PDAC (OS)

Open the PDAC breakdown →