TTC27

Across TCGA cell cohorts, TTC27 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,746 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TTC27-associated GO terms across cancer lineages are DNA replication initiation, Transcription by RNA polymerase I, and Transcription initiation at RNA polymerase I promoter. Each is linked with TTC27 in more than 14 cancer types. Because this analysis shows association rather than direction, both TTC27-to-partner and partner-to-TTC27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by TTC27-low versus TTC27-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC27→partner) and Y-score (partner→TTC27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.161	+1.150	<.001	<.001	3	14
PANCREAS	Transcription by RNA polymerase I →	+0.107	+0.602	<.001	.002	3	14
PANCREAS	Transcription initiation at RNA polymerase I promoter →	+0.129	+0.856	<.001	<.001	3	14
LUNG_NSCLC_LUSC	rRNA 5'-end processing →	+0.154	+1.000	<.001	<.001	3	13
LARGE_INTESTINE	Mitochondrial RNA processing →	+0.076	+0.657	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.154	+1.000	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,746 associations by consensus.

DNA replication initiation by TTC27 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →