TTC27

Across TCGA cell cohorts, TTC27 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC27-associated genes across cancer lineages are C9orf92, SCGB1D2, and C10orf62. Each is linked with TTC27 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC27-to-partner and partner-to-TTC27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by TTC27-low versus TTC27-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC27→partner) and Y-score (partner→TTC27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
BLOOD_Leukemia	SCGB1D2 →	+0.093	+3.177	.001	.004	3	1
BLOOD_Leukemia	C10orf62 →	+0.025	+3.269	.001	.007	3	1
LARGE_INTESTINE	IL20 →	+0.158	+2.984	.001	.005	3	1
LARGE_INTESTINE	C9orf135 →	+0.077	+3.363	.003	<.001	3	1
LARGE_INTESTINE	PSMB11 →	+0.019	+2.556	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

C9orf92 by TTC27 expression — SOFT_TISSUE

Explore this box plot interactively →