Across TCGA patient cohorts, TTC25 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC25-associated genes across cancer lineages are ASNS, Notch1, and PCNA. Each is linked with TTC25 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTC25-to-partner and partner-to-TTC25 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC25→partner) and Y-score (partner→TTC25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.526	+3.169	<.001	.018	3	3
UCEC	Notch1 →	+0.191	+1.884	.001	.030	3	2
UCEC	PCNA →	+0.244	+2.700	.007	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.159	-2.000	.026	.030	3	1
UCEC	Lck →	+0.222	+2.222	.009	.011	3	1
UCEC	MAPK_pT202_Y204 →	-0.394	-2.321	.048	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

TTC25 survival (RNA) · tumor vs normal (RNA) · all TTC25 data types