TTC23

Across TCGA patient cohorts, TTC23 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC23-associated genes across cancer lineages are ATM, JNK_pT183_Y185, and Rad50. Each is linked with TTC23 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTC23-to-partner and partner-to-TTC23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TTC23-low versus TTC23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC23→partner) and Y-score (partner→TTC23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.516	-2.700	.011	.006	3	3
UCEC	JNK_pT183_Y185 →	-0.154	-1.986	.042	.032	3	2
UCEC	Rad50 →	-0.249	-2.000	.023	.032	3	2
UCEC	ERK2 →	+0.211	+3.169	.015	.018	3	1
UCEC	FoxM1 →	+0.232	+2.700	.047	.006	3	1
UCEC	JNK2 →	+0.308	+2.834	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ATM by TTC23 expression — UCEC

Explore this box plot interactively →