TTC22

Across TCGA patient cohorts, TTC22 mutation is significantly associated with the RNA expression of many other genes, with 2,236 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC22-associated genes across cancer lineages are RN7SL601P, INTS10, and ANAPC15. Each is linked with TTC22 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC22-to-partner and partner-to-TTC22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL601P grouped by TTC22-low versus TTC22-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC22→partner) and Y-score (partner→TTC22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL601P →	+0.133	+7.731	<.001	.009	3	2
SKCM	INTS10 →	+0.758	+3.366	.004	.005	3	2
SKCM	ANAPC15 →	+0.711	+3.328	<.001	.005	3	2
SKCM	SOD1 →	+0.564	+3.328	.001	.005	3	2
SKCM	DBIP2 →	+0.126	+2.393	.004	.009	3	2
UCEC	TRIM35 →	+0.589	+3.386	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,236 associations by consensus.

RN7SL601P by TTC22 expression — BRCA

Explore this box plot interactively →