TTC22

Across TCGA patient cohorts, TTC22 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC22-associated genes across cancer lineages are ATM, EGFR_pY1068, and eIF4G. Each is linked with TTC22 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC22-to-partner and partner-to-TTC22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TTC22-low versus TTC22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC22→partner) and Y-score (partner→TTC22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.516	-2.321	.023	.035	3	2
UCEC	EGFR_pY1068 →	-0.283	-2.321	.024	.035	3	1
UCEC	eIF4G →	+0.348	+2.321	.025	.035	3	1
UCEC	A-Raf_pS299 →	-0.161	-3.169	.007	.019	3	1
UCEC	INPP4B →	-0.342	-3.169	.035	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.238	-2.999	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ATM by TTC22 expression — UCEC

Explore this box plot interactively →