TTC22

Across TCGA cell cohorts, TTC22 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,710 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible TTC22-associated GO terms across cancer lineages are Desmosome organization, Response to indole-3-methanol, and Regulation of hippocampal neuron apoptotic process. Each is linked with TTC22 in more than 10 cancer types. Because this analysis shows association rather than direction, both TTC22-to-partner and partner-to-TTC22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Desmosome organization grouped by TTC22-low versus TTC22-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC22→partner) and Y-score (partner→TTC22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Desmosome organization →	+0.385	+1.446	.002	<.001	3	11
URINARY_TRACT	Response to indole-3-methanol →	+0.235	+2.358	<.001	<.001	3	10
STOMACH	Regulation of hippocampal neuron apoptotic process →	+2.000	+1.476	<.001	.001	3	10
LUNG_NSCLC_LUSC	Leukotriene B4 catabolic process →	+1.943	+2.491	<.001	.003	3	10
STOMACH	Intracellular sodium ion homeostasis →	+0.329	+1.918	<.001	<.001	3	10
PANCREAS	Cellular response to indole-3-methanol →	+0.210	+1.873	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,710 associations by consensus.

Desmosome organization by TTC22 expression — STOMACH

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