TTC22

Across TCGA cell cohorts, TTC22 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC22-associated genes across cancer lineages are TGM7, ASB17, and KRTAP6-1. Each is linked with TTC22 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC22-to-partner and partner-to-TTC22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM7 grouped by TTC22-low versus TTC22-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC22→partner) and Y-score (partner→TTC22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TGM7 →	+0.010	+4.087	<.001	.009	3	1
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
SKIN	KRTAP6-1 →	+0.050	+4.022	<.001	.006	3	1
BLOOD_Leukemia	C20orf85 →	+0.033	+4.384	<.001	.006	3	1
BLOOD_Leukemia	ART1 →	+0.028	+3.705	<.001	.007	3	1
BLOOD_Leukemia	ZNF705A →	+0.030	+4.392	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

TGM7 by TTC22 expression — URINARY_TRACT

Explore this box plot interactively →