Across TCGA pan-cancer cohorts, TTC21B-AS1 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated TTC21B-AS1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TTC21B-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TTC21B-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCS show a favorable association.

UCEC, ACC, and CESC are the cancer types where TTC21B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.896	0.955	.001	84	view →
ACC	DFS	Median	IV	0.116	0.519	<.001	68	view →
CESC	DFS	Median	All	0.396	0.675	<.001	52	view →
KIRP	DFS	Median	IV	0.037	0.527	.004	43	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	37	view →
BLCA	OS	Median	All	0.563	0.337	.001	34	view →
LIHC	DFS	Median	All	0.357	0.498	<.001	31	view →
UCS	DFS	Median	IV	0.952	0.367	.001	28	view →
CHOL	DFS	Quartile	II,III,IV	0.114	0.741	.024	21	view →
STAD	OS	Median	All	0.741	0.636	.008	14	view →
TGCT	DFS	Tertile	All	0.377	0.786	.011	14	view →
MESO	OS	Tertile	II,III,IV	0.255	0.470	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

Exploration

Same gene, other analysis: TTC21B-AS1 tumor-vs-normal RNA expression · all TTC21B-AS1 data types