TTC19

Across TCGA patient cohorts, TTC19 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC19-associated genes across cancer lineages are FOXO3a, JNK2, and Ku80. Each is linked with TTC19 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC19-to-partner and partner-to-TTC19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by TTC19-low versus TTC19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC19→partner) and Y-score (partner→TTC19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	-0.105	-3.140	.032	.019	3	1
UCEC	JNK2 →	+0.231	+2.817	.016	.036	3	1
UCEC	Ku80 →	+0.397	+3.179	<.001	.010	3	1
UCEC	Notch1 →	+0.166	+3.009	.014	.019	3	1
UCEC	Annexin-1 →	+0.608	+3.189	.016	.010	3	1
UCEC	A-Raf_pS299 →	-0.179	-3.000	.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FOXO3a by TTC19 expression — UCEC

Explore this box plot interactively →