TTC19

Across TCGA cell cohorts, TTC19 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,178 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTC19-associated GO terms across cancer lineages are Regulation of telomere maintenance via telomerase, Negative regulation of telomere maintenance, and Cytosolic ciliogenesis. Each is linked with TTC19 in more than 10 cancer types. Because this analysis shows association rather than direction, both TTC19-to-partner and partner-to-TTC19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomere maintenance via telomerase grouped by TTC19-low versus TTC19-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC19→partner) and Y-score (partner→TTC19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of telomere maintenance via telomerase →	+0.076	+0.890	<.001	.005	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of telomere maintenance →	+0.100	+0.750	<.001	.002	3	10
LUNG_SCLC	Cytosolic ciliogenesis →	+0.117	+0.588	.001	.001	3	10
URINARY_TRACT	Purine nucleobase biosynthetic process →	+0.163	+0.959	.002	.003	3	9
UPPER_AERODIGESTIVE_TRACT	DNA biosynthetic process →	+0.076	+0.795	.001	.002	3	9
LUNG_SCLC	Glycine biosynthetic process →	+0.164	+0.582	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,178 associations by consensus.

Regulation of telomere maintenance via telomerase by TTC19 expression — URINARY_TRACT

Explore this box plot interactively →