TTC14

Across TCGA pan-cancer cohorts, TTC14 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TTC14 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TTC14 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTC14 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where TTC14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.167	1.000	.010	50	view →
PDAC	OS	Tertile	All	0.289	0.649	.014	25	view →
LUAD	OS	Median	All	0.905	0.664	.005	12	view →
GBM	DFS	Tertile	All	0.451	0.204	.004	4	view →
LSCC	DFS	Median	II,III,IV	0.451	0.877	.044	2	view →
CCRCC	OS	Tertile	All	0.812	0.958	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TTC14–HNSC (DFS)

Open the HNSC breakdown →