TTC14

Across TCGA patient cohorts, TTC14 mutation is significantly associated with the RNA expression of many other genes, with 3,978 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC14-associated genes across cancer lineages are CENPU, BUB3, and SKA1. Each is linked with TTC14 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTC14-to-partner and partner-to-TTC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by TTC14-low versus TTC14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC14→partner) and Y-score (partner→TTC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.545	+1.568	.001	.001	3	3
UCEC	BUB3 →	+0.456	+3.534	<.001	<.001	3	3
UCEC	SKA1 →	+0.706	+2.203	<.001	<.001	3	3
UCEC	DONSON →	+0.464	+2.192	<.001	<.001	3	3
UCEC	NDUFV3 →	+0.217	+1.546	.003	.001	3	3
UCEC	CENPN →	+0.763	+2.214	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,978 associations by consensus.

CENPU by TTC14 expression — UCEC

Explore this box plot interactively →