TTC14

Across TCGA patient cohorts, TTC14 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC14-associated genes across cancer lineages are FoxM1, Cyclin-B1, and PCNA. Each is linked with TTC14 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTC14-to-partner and partner-to-TTC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TTC14-low versus TTC14-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC14→partner) and Y-score (partner→TTC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FoxM1 →	+0.351	+2.820	.013	.035	3	2
LUAD	Cyclin-B1 →	+0.744	+3.000	.005	.036	3	2
UCEC	PCNA →	+0.261	+2.058	<.001	<.001	3	2
COAD	Shc_pY317 →	-0.200	-3.157	.011	.018	2	3
COAD	ASNS →	+0.528	+2.178	.004	.035	3	2
UCEC	C-Raf →	+0.145	+1.289	.001	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

FoxM1 by TTC14 expression — LUAD

Explore this box plot interactively →