TTC1

Across TCGA cell cohorts, TTC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,755 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TTC1-associated GO terms across cancer lineages are Negative regulation of mitotic nuclear division, Negative regulation of metaphase/anaphase transition of cell cycle, and Negative regulation of chromosome separation. Each is linked with TTC1 in more than 11 cancer types. Because this analysis shows association rather than direction, both TTC1-to-partner and partner-to-TTC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mitotic nuclear division grouped by TTC1-low versus TTC1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC1→partner) and Y-score (partner→TTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of mitotic nuclear division →	+0.105	+0.947	.002	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.117	+0.703	.007	.003	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome separation →	+0.117	+0.703	.007	.003	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mitotic sister chromatid separation →	+0.124	+0.759	.008	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of sister chromatid segregation →	+0.124	+0.759	.008	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mitotic sister chromatid segregation →	+0.124	+0.759	.008	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,755 associations by consensus.

Negative regulation of mitotic nuclear division by TTC1 expression — LIVER

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