TSTD2

Across TCGA patient cohorts, TSTD2 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSTD2-associated genes across cancer lineages are Rad50, Beclin, and 14-3-3_beta. Each is linked with TSTD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSTD2-to-partner and partner-to-TSTD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by TSTD2-low versus TSTD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSTD2→partner) and Y-score (partner→TSTD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.201	-1.847	.024	.008	3	2
UCEC	Beclin →	+0.078	+1.847	.025	.008	3	2
UCEC	14-3-3_beta →	-0.084	-1.973	.023	.029	3	1
UCEC	EGFR_pY1068 →	-0.222	-1.502	.016	.030	3	1
UCEC	ERK2 →	+0.181	+1.678	.010	.021	3	1
UCEC	FoxM1 →	+0.223	+2.009	.019	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Rad50 by TSTD2 expression — UCEC

Explore this box plot interactively →