TSSK3

Across TCGA pan-cancer cohorts, TSSK3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TSSK3 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TSSK3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSSK3 expression acts as an unfavorable survival marker.

MESO, UCEC, and COAD are the cancer types where TSSK3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	II,III,IV	0.039	0.407	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	DFS	Median	All	0.171	0.562	.048	3	view →
SKCM	OS	Median	All	0.118	0.323	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TSSK3–MESO (DFS)

Open the MESO breakdown →