TSSK3

Across TCGA cell cohorts, TSSK3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TSSK3-associated genes across cancer lineages are BHLHE23, APCS, and BSND. Each is linked with TSSK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSSK3-to-partner and partner-to-TSSK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BHLHE23 grouped by TSSK3-low versus TSSK3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSSK3→partner) and Y-score (partner→TSSK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BHLHE23 →	+0.011	+4.169	<.001	.008	3	1
CNS	APCS →	+0.225	+3.643	<.001	.007	3	1
CNS	BSND →	+0.055	+4.201	<.001	.003	3	1
CNS	OR4N4 →	+0.067	+3.643	.003	.007	3	1
BLOOD_Leukemia	IFNA17 →	+0.021	+4.539	<.001	.007	3	1
LARGE_INTESTINE	MAGEB4 →	+0.022	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

BHLHE23 by TSSK3 expression — CNS

Explore this box plot interactively →