Across TCGA patient cohorts, TSSK2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSSK2-associated genes across cancer lineages are TFRC, FoxM1, and Acetyl-a-Tubulin-Lys40. Each is linked with TSSK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSSK2-to-partner and partner-to-TSSK2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSSK2→partner) and Y-score (partner→TSSK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.428	+2.999	.045	.035	3	2
UCEC	FoxM1 →	+0.210	+1.906	.043	.016	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.608	+1.906	.002	.016	3	1
UCEC	MEK1 →	+0.332	+1.906	.024	.016	3	1
UCEC	mTOR_pS2448 →	-0.141	-2.680	.018	.006	3	1
UCEC	Notch1 →	+0.156	+2.335	.006	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

TSSK2 survival (RNA) · tumor vs normal (RNA) · all TSSK2 data types