Across TCGA pan-cancer cohorts, TSSC4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TSSC4 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TSSC4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSSC4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where TSSC4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.697	1.000	.006	17	view →
HNSC	DFS	Median	III,IV	0.674	0.897	.006	15	view →
LUAD	OS	Median	All	0.971	0.762	.010	6	view →
PDAC	OS	Quartile	II,III,IV	0.579	0.274	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TSSC4 tumor-vs-normal RNA expression · all TSSC4 data types