Across TCGA patient cohorts, TSSC4 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSSC4-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and p62 Lck ligand. Each is linked with TSSC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSSC4-to-partner and partner-to-TSSC4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSSC4→partner) and Y-score (partner→TSSC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.116	-2.979	.035	.036	3	1
UCEC	EGFR_pY1068 →	-0.445	-3.169	.001	.020	3	1
UCEC	p62 Lck ligand →	+0.475	+3.179	.007	.010	3	1
UCEC	Annexin-1 →	+0.741	+2.827	.010	.035	3	1
UCEC	AR →	-0.481	-3.169	.019	.020	3	1
UCEC	ATM →	-0.524	-3.169	.035	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

TSSC4 survival (RNA) · tumor vs normal (RNA) · all TSSC4 data types