Across TCGA patient cohorts, TSSC2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSSC2-associated genes across cancer lineages are JNK_pT183_Y185, p27_pT198, and ERK2. Each is linked with TSSC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSSC2-to-partner and partner-to-TSSC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSSC2→partner) and Y-score (partner→TSSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.197	-2.794	.007	.003	3	2
UCEC	p27_pT198 →	+0.121	+2.321	.009	.034	3	2
UCEC	ERK2 →	+0.219	+3.169	.009	.018	3	1
UCEC	FoxM1 →	+0.324	+2.115	.004	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.124	-2.321	.022	.033	3	1
UCEC	GATA6 →	-0.195	-2.307	.003	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

TSSC2 survival (RNA) · tumor vs normal (RNA) · all TSSC2 data types