TSR3

Across TCGA pan-cancer cohorts, TSR3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TSR3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TSR3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSR3 is over-expressed in tumor.

HNSC, KIRC, and KIRP are the cancer types where TSR3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSR3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.655	<.001	12	view →
KIRC	Female	All	+0.577	<.001	12	view →
KIRP	All	IV	+0.882	<.001	11	view →
COAD	Female	All	+0.469	<.001	10	view →
LIHC	Female	II,III,IV	+1.104	<.001	9	view →
BRCA	All	All	+0.321	.002	6	view →
LUSC	All	II,III,IV	+0.451	<.001	5	view →
CHOL	All	All	+1.725	<.001	3	view →
LUAD	All	III,IV	+0.369	.008	3	view →
KICH	Male	IV	+0.496	.049	1	view →
STAD	All	II,III,IV	+0.310	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TSR3–HNSC

Open the HNSC breakdown →