TSR2

Across TCGA patient cohorts, TSR2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,173 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible TSR2-associated genes across cancer lineages are FCGR3B, CXCL8, and USP11. Each is linked with TSR2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TSR2-to-partner and partner-to-TSR2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TSR2 versus FCGR3B in HNSC, with a Pearson correlation of -0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSR2→partner) and Y-score (partner→TSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FCGR3B →	-1.584	-0.731	<.001	<.001	3	6
LSCC	CXCL8 →	-1.887	-0.438	<.001	<.001	3	6
OV	USP11 →	+0.962	+0.319	<.001	.008	3	5
GBM	PELI3 →	+0.552	+0.296	<.001	<.001	3	5
LSCC	ZNF674 →	+0.366	+0.313	<.001	<.001	3	5
LUAD	USP27X →	+1.078	+0.285	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,173 associations by consensus.

TSR2 vs FCGR3B — HNSC

Explore this scatter interactively →