TSR2

Across TCGA patient cohorts, TSR2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSR2-associated genes across cancer lineages are Notch1, p62 Lck ligand, and PI3K-p85. Each is linked with TSR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSR2-to-partner and partner-to-TSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TSR2-low versus TSR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSR2→partner) and Y-score (partner→TSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.134	+3.013	.040	.018	3	1
UCEC	p62 Lck ligand →	+0.334	+3.169	.027	.018	3	1
UCEC	PI3K-p85 →	+0.201	+2.584	.039	.011	3	1
UCEC	Src →	+0.264	+3.026	.005	.018	3	1
UCEC	ASNS →	+0.405	+2.999	.016	.035	3	1
UCEC	CDK1 →	-0.178	-3.156	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Notch1 by TSR2 expression — UCEC

Explore this box plot interactively →