TSPYL6

Across TCGA patient cohorts, TSPYL6 mutation is significantly associated with the RNA expression of many other genes, with 3,466 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPYL6-associated genes across cancer lineages are FABP5P13, SLC25A17, and PSMA6. Each is linked with TSPYL6 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSPYL6-to-partner and partner-to-TSPYL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FABP5P13 grouped by TSPYL6-low versus TSPYL6-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPYL6→partner) and Y-score (partner→TSPYL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	FABP5P13 →	+0.135	+5.588	<.001	.004	3	2
UCEC	SLC25A17 →	+0.347	+2.534	.002	<.001	3	2
UCEC	PSMA6 →	+0.500	+3.177	.002	<.001	3	2
UCEC	PCSK1N →	-1.408	-1.785	.001	.004	3	2
COAD	ERI1 →	+0.627	+3.820	<.001	<.001	3	2
COAD	MBD2 →	+0.380	+3.196	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,466 associations by consensus.

FABP5P13 by TSPYL6 expression — BLCA

Explore this box plot interactively →