TSPYL6

Across TCGA patient cohorts, TSPYL6 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPYL6-associated genes across cancer lineages are EGFR_pY1068, MEK1, and C-Raf. Each is linked with TSPYL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPYL6-to-partner and partner-to-TSPYL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TSPYL6-low versus TSPYL6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPYL6→partner) and Y-score (partner→TSPYL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.214	-2.000	.020	.029	3	2
UCEC	MEK1 →	+0.347	+3.087	.009	<.001	3	2
UCEC	C-Raf →	+0.134	+1.807	.011	.025	3	2
UCEC	Cyclin-E2 →	+0.159	+2.125	.010	.010	3	2
COAD	G6PD →	+0.187	+1.882	.018	.031	3	1
COAD	HSP70 →	+0.476	+2.820	.045	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

EGFR_pY1068 by TSPYL6 expression — UCEC

Explore this box plot interactively →