TSPYL5

Across TCGA pan-cancer cohorts, TSPYL5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TSPYL5 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TSPYL5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TSPYL5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

UCEC, LUAD, and PDAC are the cancer types where TSPYL5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.496	1.000	.012	12	view →
LUAD	OS	Median	III,IV	0.775	0.221	.003	4	view →
PDAC	OS	Quartile	All	0.984	0.824	.019	2	view →
GBM	OS	Median	All	0.297	0.449	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TSPYL5–UCEC (OS)

Open the UCEC breakdown →