TSPYL5

Across TCGA patient cohorts, TSPYL5 mutation is significantly associated with the RNA expression of many other genes, with 2,678 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPYL5-associated genes across cancer lineages are CDH12P1, RNU6-1214P, and RNA5SP113. Each is linked with TSPYL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSPYL5-to-partner and partner-to-TSPYL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH12P1 grouped by TSPYL5-low versus TSPYL5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPYL5→partner) and Y-score (partner→TSPYL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CDH12P1 →	+0.090	+4.557	<.001	.004	3	3
HNSC	RNU6-1214P →	+0.232	+3.963	.001	.003	3	2
UCEC	RNA5SP113 →	+0.413	+3.024	<.001	<.001	3	2
CESC	RNA5SP387 →	+0.302	+4.342	<.001	.007	3	2
CESC	RNU6-13P →	+0.448	+3.691	<.001	.003	3	2
CESC	MIR599 →	+0.168	+4.144	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,678 associations by consensus.

CDH12P1 by TSPYL5 expression — COAD

Explore this box plot interactively →