TSPYL5

Across TCGA patient cohorts, TSPYL5 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPYL5-associated genes across cancer lineages are ATM, MEK1, and 4E-BP1. Each is linked with TSPYL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSPYL5-to-partner and partner-to-TSPYL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TSPYL5-low versus TSPYL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPYL5→partner) and Y-score (partner→TSPYL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.567	-2.000	<.001	.003	3	3
UCEC	MEK1 →	+0.406	+2.502	.001	.001	3	2
UCEC	4E-BP1 →	+0.446	+3.999	<.001	<.001	3	2
UCEC	eIF4E →	+0.174	+2.392	.019	<.001	3	1
UCEC	A-Raf_pS299 →	-0.115	-2.222	.006	.010	3	1
UCEC	GAPDH →	+0.412	+2.584	.029	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ATM by TSPYL5 expression — UCEC

Explore this box plot interactively →