Across TCGA patient cohorts, TSPYL1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPYL1-associated genes across cancer lineages are MSH2, Annexin_VII, and ACC1. Each is linked with TSPYL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPYL1-to-partner and partner-to-TSPYL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPYL1→partner) and Y-score (partner→TSPYL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.339	-2.973	.001	.035	3	2
UCEC	Annexin_VII →	-0.159	-2.584	.014	.011	3	2
UCEC	ACC1 →	+0.399	+3.013	.018	.018	3	1
UCEC	Ku80 →	+0.282	+2.598	.010	.006	3	1
UCEC	Notch1 →	+0.180	+2.817	.006	.036	3	1
UCEC	p62 Lck ligand →	+0.317	+2.179	.036	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

TSPYL1 survival (RNA) · tumor vs normal (RNA) · all TSPYL1 data types